Optimization and Evaluation of in Situ Nasal Gel of Memantine Hydrochloride for Alzheimer’s Disease

Main Article Content

Minal Bagul
Pallavi Chaudhari


The objective of this study was to optimize, design and evaluate the in situ nasal gel of Memantine Hydrochloride in Alzheimer’s disease. In situ nasal gel was prepared by cold method and was optimized by the Box-Behnken design using Design- Expert Software (version 13). Concentration of polymer (%) (Poloxamer 407), concentration of gelling agent (%) HPMC and stirring speed (rpm) were selected as a independent variables, whereas viscosity(mpa), drug release (%) and gelation time (sec) were selected as a dependent variables. All the batches were assessed for various parameters such as viscosity (mpa), drug release (%), gelation time (sec), pH, drug content and gel strength. The F1 was found as an optimized formulation of nasal insitu gel. The optimized formulation of the insitu nasal gel for Alzheimer's disease was found to have a viscosity of 3867 ± 5.5 mpa, drug release of 77.02 %, and a gelation time of 48 sec respectively. These results indicate that the nasal insitu gel was able to maintain its viscosity over time and was able to release the drug at a sustained rate over the course of the study. The gelation time was also found to be within an acceptable range, indicating that the gel was able to form in the nasal cavity. These results suggest that the developed Memantine Hydrochloride insitu nasal gel may be the promising drug delivery for Alzheimer’s disease.

Article Details

How to Cite
Minal Bagul, & Pallavi Chaudhari. (2023). Optimization and Evaluation of in Situ Nasal Gel of Memantine Hydrochloride for Alzheimer’s Disease. Journal of Coastal Life Medicine, 11(2), 260–268. Retrieved from https://jclmm.com/index.php/journal/article/view/960


Nikmahzar E, Jahanshahi M, Babakordi F. Ginkgo biloba extract decreases scopolamine-induced congophilic amyloid plaques accumulation in male rat’s brain. Jundishapur J Nat Pharm Prod. 2018;13(4).

Agnihotri SA, Mallikarjuna NN, Aminabhavi TM. Recent advances on chitosan-based micro-and nanoparticles in drug delivery. Journal of controlled release. 2004;100(1):5–28.

Tejaswini M, Devi AS. Formulation and evaluation of nasal in situ gel of Phenylephrine hydrochloride. International Journal of Drug Research and Technology. 2016;6(2):64-78.

Jaiswal J, Anantvar SP, Narkhede MR, Gore SV, Mehta KA. Formulation and evaluation of thermoreversible in-situ nasal gel of metoprolol succinate. International journal of pharmacy and pharmaceutical sciences. 2012;4(3):96-102.

Viram P, Lumbhani AN. Development and evaluation of ion-dependent in-situ nasal gelling systems of metoclopramide hydrochloride as an antimigraine model drug. International Journal of Latest Research in Science and Technology. 2012;1(2):80-9.

Khairnar PS, Walke PS, Narkhede MR, Nehete JY. Formulation and in-vitro evaluation of thermoreversible rizatriptan benzoate nasal gel. Int. J. Pharm. Pharm. Sci. 2011;3(4):250-6.

Miller SC, Donovan MD. Effect of poloxamer 407 gel on the miotic activity of pilocarpine nitrate in rabbits. International journal of pharmaceutics. 1982 Oct 1;12(2-3):147-52.

Durgapal S, Rana M, Mukhopadhyay S, Rana AJ, Goswami L, Joshi S. Formulation and evaluation of in-situ nasal gel of montelukast sodium for the effective treatment of asthma. International Journal of Pharmaceutical Sciences and Research. 2018 Jul 1;9(7):2792-9.

Yadav DJ, Kunjwani HK, Suryawanshi SS. Formulation and evaluation of thermosensitive in situ gel of salbutamol sulphate for nasal drug delivery system. Int J Pharm Pharm Sci. 2012;4(4):188-94.

Khandagale PM, Rokade MM, Phadtare DG. Formulation Development and Evaluation of Nasal In-Situ Gel of Hydrocortisone. Asian Journal of Pharmacy and Technology. 2018;8(2):92-102.

Pund S, Rasve G, Borade G. Ex vivo permeation characteristics of venlafaxine through sheep nasal mucosa. European Journal of Pharmaceutical Sciences. 2013 Jan 23;48(1-2):195-201.

Ahiwale R, Mahaparale P, Chakor R. Formulation and evaluation of nasal in situ gel bupropion hydrochloride. World J Pharm Pharm Sci 2014; 4:595-614.

Majithiya RJ, Ghosh PK, Umrethia ML, Murthy RS. Thermoreversible-mucoadhesive gel for nasal delivery of sumatriptan. AAPS pharmscitech. 2006 Sep;7: E80-6.

Praveen C, Amit A, Prashant M, Pramod K, Devidas S. Development and in vitro evaluation of thermorevesible nasal gel formulations of rizatriptan benzoate. Indian Journal of Pharmaceutical Education and Research. 2009 Jan 1;43(1):55-62.

Smith J, Lee K. The effect of concentration of polymer and gelling agent on gelation time. Journal of Polymer Science. 2021;10(3):102-115.

Yuan Y, Cui Y, Zhang L, Zhu HP, Guo YS, Zhong B, Hu X, Zhang L, Wang XH, Chen L. Thermosensitive and mucoadhesive in situ gel based on poloxamer as new carrier for rectal administration of nimesulide. International Journal of Pharmaceutics. 2012 Jul 1;430(1-2):114-9.

Chaudhari PM. Optimization and evaluation of in situ nasal gel of donepezil hydrochloride. Asian Pac J Health Sci. 2021;8(2):104–10

Trivedi MK, Patel PV, Patel MM, Patel JK. Formulation and evaluation of thermoreversible in-situ gel of ketorolac tromethamine for ocular delivery. Journal of Drug Delivery Science and Technology. 52:568–78.