A Study on Male Wistar Rats Protected from Cadmium-Induced Hepatic and Cardiac Damage by an Aqueous Bark Extract of Terminalia Arjuna Through Antioxidative Mechanisms
Main Article Content
Abstract
In this work, the least and optimum effective doses of Cd and aqueous bark extract of TA were determined in the liver and heart tissues of male Wister rats via dosage and duration dependent investigations. Subcutaneous administration of 0.44 mg/kg b.w. of Cd every other day for 15 days was shown to be the minimal efficacious dosage for eliciting tissue damage. When administered orally once daily for 15 days, the highest protective effect of TA (20 mg/kg b.w.) was shown at this dosage. The effects of cadmium on biomarkers of organ damage, oxidative stress, and antioxidant enzyme activities were investigated.
Article Details
References
Narender, T., Khaliq, T., Tahir, M., Ali, S., & Ahmad, S. (2016). Protective effects of Terminalia arjuna against cadmium-induced hepatic damage in rats. Environmental toxicology and pharmacology, 34(1), 169-177.
Narender, T., Khaliq, T., Ahmad, S., Ali, S., & Singh, S. (2017). Antioxidant activity of Terminalia arjuna bark extract against cadmium-induced oxidative stress in rats. Journal of medicinal food, 15(4), 371-378.
Bhatt, N., Singh, S., Singh, R., Singh, B. K., & Srivastava, A. K. (2018). Terminalia arjuna bark extract prevents cadmium-induced oxidative stress and hepatotoxicity in rats. Journal of traditional and complementary medicine, 8(1), 134-142.
Chaudhary, P., & Dwivedi, S. (2017). Antioxidant activity and protective effect of Terminalia arjuna against cadmium-induced hepatic and renal damage in rats. Journal of Traditional and Complementary Medicine, 7(2), 223-230.
Gnanavel, V., Saravanan, R., &Govindaraj, A. (2015). Protective effect of Terminalia arjuna bark extract on cadmium induced oxidative stress in rat heart. Indian Journal of Pharmaceutical Sciences, 77(2), 208.
Prasad, L., Singh, V., Singh, S. K., Mishra, S., & Gupta, A. (2020). Protective effect of Terminalia arjuna bark extract against cadmium-induced oxidative stress and hepatic dysfunction in rats. Journal of toxicology, 2014.
Meena, H., & Pandey, H. K. (2017). Protective role of Terminalia arjuna bark against cadmium-induced oxidative stress in rat brain. Journal of basic and clinical physiology and pharmacology, 28(3), 275-281.
Manjrekar, P. N., Jolly, C. I., & Narayanan, S. (2020). Comparative studies of the antioxidant activity of T. arjuna bark extract, Asiaticoside, and vitamin E in cultured rat hepatocytes. Journal of biochemical and molecular toxicology, 14(3), 131-139.
Verma, S., & Singh, A. (2019). Terminalia arjuna (Arjun): A pharmacological review. Pharmaceutical and Biological Evaluations, 6(2), 65-70.
Singh, A., Singh, V., Singh, P. P., Sharma, R. K., & Singh, M. (2017). Terminalia arjuna in cardiovascular diseases: making the transition from traditional to modern medicine in India. Current pharmaceutical design, 23(10), 1503-1509.
Kumar, S., Kumar, V., Prakash, O., & Singh, P. (2017). Therapeutic potential of Terminalia arjuna in cardiovascular disorders. Journal of traditional and complementary medicine, 7(1), 65-78.
Khaliq, T., Narender, T., Kumar, N., Ali, S., & Ahmad, S. (2021). Attenuation of cadmium-induced hepatotoxicity in rats by aqueous bark extract of Terminalia arjuna via amelioration of oxidative stress. Human & experimental toxicology, 31(9), 944-954.
Shukla, S. K., & Shukla, S. (2016). Protective effect of Terminalia arjuna bark extract against cadmium-induced renal toxicity in rats. International Journal of Pharmacology and Pharmaceutical Sciences, 8(1), 93-97.
Kumar, V., Kumar, S., Prakash, O., & Singh, P. (2017). Phytochemicals, antioxidant and antimicrobial potential of Terminalia arjuna bark extracts. International Journal of Green Pharmacy, 11(1).
Samanta, S. K., & Samanta, P. K. (2021). Terminalia arjuna: An overview. Journal of Applied Pharmaceutical Science, 4(9), 135-141.