Metformin Causes Vitamin B12 Deficiency

Main Article Content

Suresh Kanna S.
Srinivasa Rao Gopisetty
Kavuru Naga Siri
Nitharsha Prakash
Goutham Kumar A. P.

Abstract

Metformin is a first drug of choice of oral diabetic drug for hyperglycemia in diabetes is generally regarded as having few cause vitamin B12deficiency.Ithasbeenreportedthatanaverageof6%to30%ofpatients could show vitamin B12 deficiency due to metformin use. The 2017 American Diabetes Association treatment guidelines now recommend regular monitoring of vitamin B 12 levels in patients with diabetes taking metformin. Metforminal so causes VitB12deficiencywhichisarareside effect of prolonged metformin therapy. Many studies showed the inverse relationship between the prolonged usage and dosage of metformin usage and B12 serum levels.

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How to Cite
Kanna S., S. ., Rao Gopisetty, S. ., Naga Siri, K. ., Prakash, N. ., & A. P., G. K. . (2023). Metformin Causes Vitamin B12 Deficiency. Journal of Coastal Life Medicine, 11(1), 239–243. Retrieved from https://jclmm.com/index.php/journal/article/view/317
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References

Natali A, Ferrannini E. Effects of metformin and thiazolidinediones on suppression of hepatic glucose production and stimulation of glucose uptake in type 2 diabetes: A systematic review. Diabetologia. 2006;49(3):434-41.

Tomkin GH, Hadden DR, Weaver JA, Montgomery DA. Vitamin-B12 statusof patients on long-term metformin therapy. British Medical Journal. 1971;2(5763):685-7

Ahmed MA, Muntingh G, Rheeder P. Vitamin B12 deficiency in metformin treated type-2 diabetes patients, prevalence and association with peripheral neuropathy. BMC Pharmacology and Toxicology. 2016;17(1):44.

Chapman LE, Darling AL, Brown JE. Association between metformin and Vitamin B (12) deficiency in patients with type 2 diabetes: A systematic review and meta-analysis. Diabetes and Metabolism. 2016;42(5):316-27.

Liu Q, Li S, Quan H, Li J. Vitamin B12 status in metformin treated patients: Systematic review. PLoS One. 2014;9(6):e100379.

Briani C, Dalla TC, Citton V, Manara R, Pompanin S, Binotto G, et al. Cobalamin deficiency: Clinical picture and radiological findings. Nutrients. 2013;5(11):45239

Singh AK, Kumar A, Karmakar D, Jha RK. Association of B12 deficiency an clinical neuropathy with metformin use in type 2 diabetes patients. Journal of Postgraduate Medicine. 2013;59(4):257.