Comparative Standardization of the Ayurvedic Formulation Trikatu Churna: A Polyherbal Mixture
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Abstract
People are shifting to using herbal medical goods in the current global healthcare system. The utilization of herbs and awareness in conventional medicine has increased exponentially. The majorities of the ancient systems of medicine (namely Ayurveda, Unani, Homeopathy, and Yoga) is effective but have certain gaps in standardizations, hence it is crucial to properly integrate current scientific procedures and old knowledge. An Ayurvedic polyherbal composition called Trikatu Churna is effective for treating a variety of illnesses and problems. The authenticity of the herbs included in a preparation determines its effectiveness. The first and most important stage in standardizing herbal formulation is the authentication of plants through anatomical research. Aim: The objective of the study is comparative standardization of commercial and in-house ayurvedic formulation Trikatu Churna by it pharmacognostic examinations, including macroscopic, microscopic, and chemical tests including preliminary phytochemical, physico-chemical constants, and TLC profile. Methods: The quality paper's standard methods were followed. Results: Macro-microscopic, preliminary phyto-chemical, and TLC analyses of the in-house and commercial formulation has been compared and documented. Conclusion: The study's findings are useful in standardizing the polyherbal Ayurvedic formula Trikatu Churna, which will increase its reputation as an Ayurvedic medicine around the world.
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References
Mukherjee PK, Wahile A. Integrated Approaches towards Drug Development from Ayurveda and Other Indian System of Medicines. Journal of Ethnopharmacology. 2006; 103: 25-35. DOI: 10.1016/j.jep.2005.09.024
Barnes J, Anderson LA, Phillipson JD. Herbal Medicine. 3rd ed. Pharmaceutical Press: London; 2007. 1-23p.
Bodeker, Gerard, Ong, Chi-Keong, Grundy, Chris, Burford, Gemma, Shein, Kin. WHO global atlas of traditional, complementary and alternative medicine. Kobe, Japan: WHO Centre for Health Development; 2005. https://apps.who.int/iris/handle/10665/43108
Mukharjee PK. Quality control of herbal drugs - An approach to evaluation of botanicals. Business Horizons Pharmaceuticals Publications: New Delhi; 2002.
Lazarowych NJ, Pekos P. Use of Fingerprinting and marker compounds for identification and standardization of botanical drugs: strategies for applying Pharmaceutical HPLC analysis to Herbal Products. Drug Information Journal. 1998; 32: 497-512.
World Health Organization. Quality control methods for medicinal plant materials. World Health Organization. 1998 https://apps.who.int/iris/handle/10665/41986
Kokate CK, Gokhale SB. Practical Pharmacognosy. 2nd ed. Pune: Nirali Prakashan; 2001. 14-19p.
Chamundeeswari D, Kanimozhi P, Vasanthkumar, C.Umamaheswara Reddy. Sri Ramachandra Journal of Medicine. 2007; 39-43.
Harwansh RK, Mukherjee K, Bhadra S, Kar A, Bahadur S, Mitra A, Mukherjee PK. Cytochrome P450 inhibitory potential and RP-HPLC standardization of Trikatu-A Rasayana from Indian Ayurveda. J. Ethnopharmacology. 2014; 153: 674–681.
Tambekar DH, Dahikar SB. Antibacterial Potential of some Herbal Preparation: An Alternative Medicine in treatment of enteric bacterial infection. International Journal of Pharmacy and Pharmaceutical Sciences. 2010; 2(4):176-179.
Reddy BU, Seetharam YN. Antimicrobial and Analgesic activities of Trikatu Churna and its ingredients. Pharmacologyonline. 2009; 3:489- 495.
Malvankar PR and Abhyankar MM. Antimicrobial activity of Water Extracts of Trikatu Churna and its Individual Ingredient. International Journal of Pharmaceutical Sciences and Research. 2012; 3(4):1087-1089.
Johri RK, Zutshi U. An ayurvedic formulation Trikatu and its constituents. J. Ethnopharmacology. 1992; 37: 85–91.
Pole S. Ayurvedic Medicine: The Principles of Traditional Practices. Churchill Livingstone: Elsevier; 2006. 302-303p.
Lee KB, Shin KH, Wan WS. Central nervous depressant and anti-inflammatory activity of piperine. Archives Pharma. Res. 1984; 1:127–132.
Murunikkara V, Pragasam SJ, Kodandaraman G, Sabina EP, Rasool M. Anti-inflammatory effect of piperine in adjuvant induced arthritic rats–a biochemical approach. Inflammation. 2012; 35:1348-135. DOI: 10.1007/s10753-012-9448-3.
The Ayurvedic Formulary of India. 2nd ed. Part I, Government of India, Ministry of Health and Family Welfare: New Delhi. 2003;113p
Sabina EP, Nagar S, Rasool M. A role of piperine on monosodium urate crystal-induced inflammation – an experimental model of gouty arthritis. Inflammation. 2011; 34: 184-192.
The 2002 United States Pharmacopoeia and National Formulary, USP 25 NF 19/National Formulary 20, Rockville, MD, U. S. Pharmacopoeia Convention, Inc. 2002
Biswajyoti Patgiri, Hardik Soni, Surendra Bhatt. Evaluation of stability study of Ayurvedic formulation-Rasayana Churna. Journal of Pharmacognosy and Phytochemistry. 2014; 2 (5): 126-130.
Telrandhe UB, Hemalatha S and Modi A. Pharmacognostic and Phytochemical investigation on Root of Cadaba farinosa Forsk. International Journal of Pharma and Bio Sciences. 2010; 1(2):1-13.
Gupta P, Nagwansi D and Gupta SP. Comparative standardization of a polyherbal ayurvedic formulation trikatu churna. Journal of Chemical and Pharmaceutical Research. 2015; 7(12):191-196.
Sasidharan S, Chen Y, Saravanan D, Sundram KM, Latha LY. Extraction, Isolation and Characterization of Bioactive Compounds from plant’s extracts. Afr J Tradit Complement Altern Med. 2011; 8(1): 1-10.
Chothani DL, Patel MB, Mishra SH. HPTLC Fingerprint Profile and Isolation of Marker Compound of Ruellia tuberose. Chromatography Research International. 2012; doi:10.1155/2012/180103
Yadav NP & Dixit VK. Recent Approaches in Herbal Drug Standardization. Int J Biol. 2008; 2:195-203.