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Objectives of Study
To study the spectrum and proportion of cervical pathologies in aceto-white areas of the cervix.
This cross-sectional study was conducted by Department of Obstetrics and Gynaecology. A mass screening for cervical cancer among women of age group 30-49 years of age in Vijaypura district was conducted. During screening women subjected for visual inspection of acetic acid (VIA). All women with aceto-white areas were enrolled in the study after considering inclusion and exclusion criteria. The aceto-white areas were subjected for biopsy, and the histopathological study of specimens was conducted .The results were noted.
A total of 880 eligible women screened of which 72 women (8.2%) had aceto-white lesions on cervix. The histopathological report of biopsy specimen showed chronic cervicitis 61 (82.4%) out of 72 participants. 5 of biopsy report showed premalignant changes (4 LSIL, 1 HSIL) (6.8%). 1 biopsy report showed cervical cancer (1.4%).
Chronic cervicitis is the most common condition to produce aceto white areas in VIA. It is prudent to treat the cervical infection/inflammation before subjecting acetowhite areas on VIA to biopsy to rule out malignancy.
2008, American Society for Colposcopy and Cervical Pathology, Journal of Lower Genital Tract Disease, Volume 12, Number 4, 2008.
Source Globocan 2020 [internet] Available from: https://gco.iarc.fr/today/data/factsheets/populations/356-india-fact-sheets.pdf.
Poli UR, Bidinger PD, Gowrishankar S. Visual Inspection with Acetic Acid (VIA) Screening Program: 7 years’ experience in Early Detection of Cervical Cancer and Pre-Cancers in Rural South India. Indian J Community Med. 2015 Jul-Sep.
Longworth MS, Laimins LA. Pathogenesis of human papillomaviruses in differentiating epithelia. Microbiol Mol Biol Rev. 2004 Jun.
Tulay P, Serakinci N. The role of human papillomaviruses in cancer progression. Journal of Cancer Metastasis and Treatment. 2016.
Burd EM. Human papilloma virus and cervical cancer. Clin Microbiol Rev. 2003.
Tomaić V. Functional Roles of E6 and E7 Oncoproteins in HPV-Induced Malignancies at Diverse Anatomical Sites. Cancers (Basel). 2016 Oct 19.
Vedantham H, Silver MI, Kalpana B, Rekha C, Karuna BP, Vidyadhari K, Mrudula S, Ronnett BM, Vijayaraghavan K, Ramakrishna G, Sowjanya P, Laxmi S, Shah KV, Gravitt PE; CATCH Study Team. Determinants of VIA (Visual Inspection of the Cervix After Acetic Acid Application) positivity in cervical cancer screening of women in a peri-urban area in Andhra Pradesh, India. Cancer Epidemiol Biomarkers Prev. 2010 May;19.
Sankaranayanan R, Basu P, Wesley R, Mahe C, Keita N, Mbalawa CC. Accuracy of visual screening for cervical neoplasia: Results from IARC multicentre study in India and Africa. Int J Cancer. 2004;
Sankaranarayanan R, Nene BM, Shastri SS, et al. HPV screening for cervical cancer in rural India. N Engl J Med. 2009.