Herbal Anxiolytics

Main Article Content

Dilsar Gohil
Rajesh Maheshwari
Falakaara Saiyed
Krupa Joshi


Stress has become an unwelcome companion in modern society, causing many to suffer from anxiety, which can have a significant impact on daily life. While a certain amount of anxiety and stress can be useful, chronic stress can lead to anxiety that interferes with normal activities. Recent studies suggest that anxiety is caused by a malfunction in neurotransmitter activity and their receptors, making it an area of critical interest. Fortunately, plants have been used for centuries to heal illnesses, and traditional medicinal practices, such as Ayurveda and Unani, continue to utilize natural remedies to promote longevity and good health. The World Health Organization recognizes the efficacy of these herbal remedies for global health concerns. This comprehensive review categorizes the most popular herbal remedies for anxiety, providing a useful guide for those seeking natural alternatives to pharmaceutical drugs and medications. By highlighting the potential of natural herbs and herbal blends, individuals can explore safe and effective treatments for anxiety that have few side effects. With this knowledge, individuals can find relief from the burden of anxiety and experience the peace of mind and well-being that come with natural healing remedies.

Article Details

How to Cite
Dilsar Gohil, Rajesh Maheshwari, Falakaara Saiyed, & Krupa Joshi. (2023). Herbal Anxiolytics. Journal of Coastal Life Medicine, 11(2), 367–374. Retrieved from https://jclmm.com/index.php/journal/article/view/1004


Ernst, E. Herbal remedies for anxiety—A systematic review of controlled clinical trials. Phytomedicine 2006, 13, 205–208.

Harvey, A.G. Insomnia: Symptom or diagnosis? Clin. Psychol. Rev. 2001, 21, 1037–1059.

Kucharczyk, E.R.; Morgan, K.; Hall, A.P. The occupational impact of sleep quality and insomnia symptoms. Sleep Med. Rev. 2012, 16, 547–559.

McIntyre, E.; Saliba, A.J.; Wiener, K.K.; Sarris, J. Prevalence and predictors of herbal medicine use in adults experiencing anxiety: A critical review of the literature. Adv. Integr. Med. 2015, 2, 38–48.

Kogadeeva, M.; Zamboni, N. SUMOFLUX: A Generalized Method for Targeted 13C Metabolic Flux Ratio Analysis. PLoS Comput. Biol. 2016, 12, e1005109.

Lydiard, R.B.; Rickels, K.; Herman, B.; Feltner, D.E. Comparative efficacy of pregabalin and benzodiazepines in treating the psychic and somatic symptoms of generalized anxiety disorder. Int. J. Neuropsychopharmacol. 2010, 13, 229–241.

Hoehn-Saric, R. Psychic and somatic anxiety: Worries, somatic symptoms and physiological changes. Acta Psychiatr. Scand. 1998, 393, 32–38.

Lakhan, S.E.; Vieira, K.F. Nutritional and herbal supplements for anxiety and anxiety-related disorders: Systematic review. Nutr. J. 2010, 9, 42.

Ohayon, M.M. Epidemiology of insomnia: What we know and what we still need to learn. Sleep Med. Rev. 2002, 6, 97–111.

Lydiard, R.B. The role of GABA in anxiety disorders. J. Clin. Psychiatry 2003, 64 [Suppl. 3], 21–27.

Kalueff, A.V.; Nutt, D.J. Role of GABA in anxiety and depression. Depress. Anxiety 2007, 24, 495–517.

Garakani, A.; Murrough, J.W.; Freire, R.C.; Thom, R.P.; Larkin, K.; Buono, F.D.; Iosifescu, D.V. Pharmacotherapy of Anxiety Disorders: Current and Emerging Treatment Options. Front. Psychiatry 2020, 11, 595584.

Koen, N.; Stein, D.J. Pharmacotherapy of anxiety disorders: A critical review. Dialogues Clin. Neurosci. 2011, 13, 423–437.

Stewart, S.A. The effects of benzodiazepines on cognition. J. Clin. Psychiatry 2005, 66 [Suppl. 2], 9–13.

Uzun, S.; Kozumplik, O.; Jakovljevic, M.; Sedic, B. Side effects of treatment with benzodiazepines. Psychiatr. Danub. 2010, 22, 90–93.

Ji, X.; Ivers, H.; Beaulieu-Bonneau, S.; Morin, C.M. Complementary and alternative treatments for insomnia/insomnia-depressionanxiety symptom cluster: Meta-analysis of English and Chinese literature. Sleep Med. Rev. 2021, 58, 101445.

Tilburt, J.C.; Kaptchuk, T.J. Herbal medicine research and global health: An ethical analysis. Bull. World Health Organ. 2008, 86, 594–599.

Gasparini, M.; Aurilia, C.; Lubian, D.; Testa, M. Herbal remedies and the self-treatment of stress: An Italian survey. Eur. J. Integr. Med. 2016, 8, 465–470.

Kinrys, G.; Coleman, E.; Rothstein, E. Natural remedies for anxiety disorders: Potential use and clinical applications. Depress. Anxiety 2009, 26, 259–265.

Leach, M.J.; Page, A.T. Herbal medicine for insomnia: A systematic review and meta-analysis. Sleep Med. Rev. 2015, 24, 1–12.

Pollack, M. H., Otto, M. W., Roy-Byrne, P. P., Coplan, J. D., Rothbaum, B. O., Simon, N. M., et al. [2008]. Novel treatment approaches for refractory anxiety disorders. Focus, 6, 486–495.

Ravindran, L. N., & Stein, M. B. [2010]. The pharmacologic treatment of anxiety disorders. Journal of Clinical Psychiatry, 71, 839–854.

Bakish, D., Hooper, C. L., West, D. L., Miller, C., Blanchard, A., & Bashir, F. [1995]. Moclobemide and specific serotonin re-uptake inhibitor combination treatment of resistant anxiety and depressive disorders. Human Psychopharmacology: Clinical and Experimental, 10, 105–109.

Goddard, A. W., Brouette, T., Almai, A., Jetty, P., Woods, S. W., & Charney, D. [2001]. Early coadministrationof clonazepamwithsertraline forpanicdisorder.Archives of General Psychiatry, 58, 681–686.

Otto, M. W., McHugh, R. K., Simon, N. M., Farach, F. J., Worthington, J. J., & Pollack, M. H. [2010]. Efficacy of CBT for benzodiazepine discontinuation in patients with panic disorder:further evaluation. Behaviour Research and Therapy, 48, 720–727

Feltner, D. E., Wittchen, H.-U., Kavoussi, R., Brock, J., Baldinetti, F., & Pande, A. C. [2008]. Long-term efficacy of pregabalin in generalized anxiety disorder. International Clinical Psychopharmacology, 23, 18–28.

Urschel, H. C., Hanselka, L. L., & Baron, M. [2011]. A controlled trial of flumazenil and gabapentin for initial treatment of methylamphetamine dependence. Journal of Psychopharmacology, 25, 254–2.

Davidson, J. R. T., DuPont, R. L., Hedges, D., & Haskins, J. T. [1999]. Efficacy, safety, and tolerability of venlafaxine extended release and buspirone in outpatients with generalized anxiety disorder. Journal of Clinical Psychiatry, 60, 528–535.

Loi, M.C.; Maxia, L.; Maxia, A. Ethnobotanical Comparison Between the Villages of Escolca and Lotzorai [Sardinia, Italy]. J. Herbs Spices Med. Plants 2005, 2005, 67–84.

Foddis, C.; Maxia, A. Le piante utilizzate nella medicina popolare dell’Ogliastra [Sardegna centro-orientale] per la cura delle patologie del sistema muscolo-scheletrico. Rend. Semin. Fac. Sci. Univ. Cagliari 2006, 76, 17–28.

Sanna, C.; Ballero, M.; Maxia, A. Le piante medicinali utilizzate contro le patologie epidermiche in Ogliastra [Sardegna centroorientale]. Atti Soc. Toscana Sci. Nat. Mem. Ser. B 2006, 113, 73–82.

Vitalini, S.; Iriti, M.; Puricelli, C.; Ciuchi, D.; Segale, A.; Fico, G. Traditional knowledge on medicinal and food plants used in Val San Giacomo [Sondrio, Italy]—An alpine ethnobotanical study. J. Ethnopharmacol. 2013, 145, 517–529.63

Mattalia, G.; Sõukand, R.; Corvo, P.; Pieroni, A. Dissymmetry at the Border: Wild Food and Medicinal Ethnobotany of Slovenes and Friulians in NE Italy. Econ. Bot. 2020, 74, 1–14.

Motti, R.; Bonanomi, G.; Emrick, S.; Lanzotti, V. Traditional Herbal Remedies Used in women’s Health Care in Italy: A Review. Hum. Ecol. 2019, 47, 941–972

Vitalini, S.; Puricelli, C.; Mikerezi, I.; Iriti, M. Plants, people and traditions: Ethnobotanical survey in the Lombard Stelvio National Park and neighbouring areas [Central Alps, Italy]. J. Ethnopharmacol. 2015, 173, 435–458.

Abourashed, E.A.; Koetter, U.; Brattstrom, A. In vitro binding experiments with a Valerian, hops and their fixed combination extract to selected central nervous system receptors. Phytomedicine 2004, 11, 633–638.

Aoshima, H.; Takeda, K.; Okita, Y.; Hossain, S.J.; Koda, H.; Kiso, Y. Effects of beer and hop on ionotropic gamma-aminobutyric acid receptors. J. Agric. Food Chem. 2006, 54, 2514–2519.

Mautone, M.; De Martino, L.; De Feo, V. Ethnobotanical research in Cava de’ Tirreni area, Southern Italy. J. Ethnobiol. Ethnomed. 2019, 15, 50.

Guarrera, P.M.; Forti, G.; Marignoli, S. Ethnobotanical and ethnomedicinal uses of plants in the district of Acquapendente. J. Ethnopharmacol. 2005, 96, 429–444.

Menale, B.; De Castro, O.; Cascone, C.; Muoio, R. Ethnobotanical investigation on medicinal plants in the Vesuvio National Park. J. Ethnopharmacol. 2016, 192, 320–349.

Buchbauer, G.; Jirovetz, L.; Jager, W.; Dietrich, H.; Plank, C. Aromatherapy: Evidence for sedative effects of the essential oil of lavender after inhalation. Z. Nat. C 1991, 46, 1067–1072.

Bradley, B.F.; Starkey, N.J.; Brown, S.L.; Lea, R.W. Anxiolytic effects of Lavandula angustifolia odour on the Mongolian gerbil elevated plus maze. J. Ethnopharmacol. 2007, 111, 517–525.

Shaw, D.; Annett, J.M.; Doherty, B.; Leslie, J.C. Anxiolytic effects of lavender oil inhalation on open-field behaviour in rats. Phytomedicine 2007, 14, 613–620.

Gasparetto, J.C.; Martins, C.A.; Hayashi, S.S.; Otuky, M.F.; Pontarolo, R. Ethnobotanical and scientific aspects of Malva sylvestris L.: A millennial herbal medicine. J. Pharm. Pharmacol. 2012, 64, 172–189.

Geraci, A.; Amato, F.; Di Noto, G.; Bazan, G.; Schicchi, R. The wild taxa utilized as vegetables in Sicily [Italy]: A traditional component of the Mediterranean diet. J. Ethnobiol. Ethnomed. 2018, 14, 14

Savo, V.; Giulia, C.; Maria, G.P.; David, R. Folk phytotherapy of the Amalfi Coast. J. Ethnopharmacol. 2011, 135, 376–392.

Lucchetti, L.; Zitti, S.; Taffetani, F. Ethnobotanical uses in the Ancona district. J. Ethnobiol. Ethnomed. 2019, 15, 9.

Yang, B.; Liu, P. Composition and health effects of phenolic compounds in hawthorn [Crataegus spp.] of different origins. J. Sci. Food Agric. 2012, 92, 1578–1590.

Mann, C.; Staba, E.J. The chemistry, pharmacology, and commercial formulations of Chamomile. J. Herbs Spices Med. Plants 1986, 1, 235–280.

Medina, J.H.; Viola, H.; Wolfman, C.; Marder, M.; Wasowski, C.; Calvo, D.; Paladini, A.C. Neuroactive flavonoids: New ligands for the Benzodiazepine receptors. Phytomedicine 1998, 5, 235–243.

WCSP World Checklist of Selected Plant Families. Facilitated by the Royal Botanic Gardens. Available online: http://wcsp. science.kew.org/ [accessed on 21 April 2021]s.

Guarrera, P.M. Food medicine and minor nourishment in the folk traditions of Central Italy [Marche, Abruzzo and Latium]. Fitoterapia 2003, 74, 515–544.

Vitalini, S.; Tome, F.; Fico, G. Traditional uses of medicinal plants in Valvestino [Italy]. J. Ethnopharmacol. 2009, 121, 106–116.

Miraj, S.; Azizi, N.; Kiani, S. A review of chemical components and pharmacological effects of Melissa officinalis L. Der Pharm. Lett. 2016, 8, 229–237.

Pignatti, S. Flora D’italia; Edagricole: Bologna, Italy, 1982; Volume II.

Masihuddin, M.; Jafri, M.A.; Siddiqui, A.; Chaudhary, S. Traditional uses, phytochemistry and pharmacological activities of papaver somniferum with special reference of unani medicine an updated review. J. Drug Deliv. Ther. 2018, 8, 110–114.

Bruni, A.; Ballero, M.; Poli, F. Quantitative ethnopharmacological study of the Campidano Valley and Urzulei district, Sardinia, Italy. J. Ethnopharmacol. 1997, 57, 97–124.

Pieroni, A.; Quave, C.L. Traditional pharmacopoeias and medicines among Albanians and Italians in southern Italy: A comparison. J. Ethnopharmacol. 2005, 101, 258–270.

Grauso, L.; de Falco, B.; Motti, R.; Lanzotti, V. Corn poppy, Papaver rhoeas L.: A critical review of its botany, phytochemistry and pharmacology. Phytochem. Rev. 2020, 20, 227–248.-

Jiang, X.; Zhang, J.C.; Liu, Y.W.; Fang, Y. Studies on chemical constituents of Valeriana officinalis. J. Chin. Med. Mater. 2007, 30, 1391–1393.

Janot, M.M.; Guilhem, J.; Contz, O.; Venera, G.; Cionga, E. Contribution to the study of valerian alcaloids [Valeriana officinalis, L.]: Actinidine and naphthyridylmethylketone, a new alkaloid [author’s transl]. Ann. Pharm. Fr. 1979, 37, 413–420.

Torssell, K.; Wahlberg, K. Isolation, structure and synthesis of alkaloids from Valeriana officinalis L. Acta Chem. Scand. 1967, 21, 53–62.

Nandhini, S.; Narayanan, K.B.; Ilango, K. Valeriana Officinalis: A review of its traditional uses, phytochemistry and pharmacology. Asian J. Pharm. Clin. Res. 2018, 11, 36–41.

Aguirre-Hernández, E.; González-Trujano, M.; Terrazas, T.; Herrera Santoyo, J.; Guevara-Fefer, P. Anxiolytic and sedative-like effects of flavonoids from Tilia americana var. mexicana: GABAergic and serotonergic participation. Salud Ment. 2016, 39, 37–46.

Heinrich, M.; Kufer, J.; Leonti, M.; Pardo-de-Santayana, M. Ethnobotany and ethnopharmacology—Interdisciplinary links with the historical sciences. J. Ethnopharmacol. 2006, 107, 157–160.

Motti, R.; Motti, P. An Ethnobotanical Survey of Useful Plants in the Agro Nocerino Sarnese [Campania, Southern Italy]. Hum. Ecol. 2017, 45, 865–878.

Palmese, M.T.; Uncini Manganelli, R.E.; Tomei, P.E. An ethno-pharmacobotanical survey in the Sarrabus district [south-east Sardinia]. Fitoterapia 2001, 72, 619–643.

Diego, M.A.; Jones, N.A.; Field, T.; Hernandez-Reif, M.; Schanberg, S.; Kuhn, C.; McAdam, V.; Galamaga, R.; Galamaga, M. Aromatherapy positively affects mood, EEG patterns of alertness and math computations. Int. J. Neurosci. 1998, 96, 217–224.

Park, M.K.; Lee, E.S. The effect of aroma inhalation method on stress responses of nursing students. J. Korean Acad. Nurs. 2004, 34, 344–351.